Iron content titanium dioxide nanoparticles as exogenous contrast agent for tissue imaging using swept-source optical coherence tomography

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dc.contributor.authorBarkhade, Tejal
dc.contributor.authorIndoliya, Abhishek
dc.contributor.authorPoddar, Raju
dc.contributor.authorMahapatra, Santosh Kumar
dc.contributor.authorBanerjee, Indrani
dc.date.accessioned2024-01-21T10:42:27Z
dc.date.accessioned2024-08-13T12:44:29Z
dc.date.available2024-01-21T10:42:27Z
dc.date.available2024-08-13T12:44:29Z
dc.date.issued2021-01-08T00:00:00
dc.description.abstractEx vivo tissue imaging was performed by swept-source optical coherence tomography (SS-OCT) using titanium dioxide (TiO2) and Fe content TiO2 nanoparticles (NPs). The comparative effects of TiO2 and Fe content TiO2 NPs in terms of contrast enhancement, penetration, scattering, and accumulation in the chicken breast tissue have been monitored at different exposure times. Powder NP samples were synthesized using the sol-gel method, and characterization was carried out via transmission electron microscopy, x-ray photoelectron spectroscopy, and diffuse reflectance spectroscopy techniques. Fe incorporation in the TiO2 matrix reduces its toxic effect on tissue skin and produces a safe exogenous contrast agent, which is analyzed by SS-OCT. The scattering coefficients and contrast to noise ratio of the tissues with and without NPs were determined to study the imaging efficacy. The improvement in the coefficient was observed with an increase in the exposure time of NPs. Nano-TiO2 has shown the ability to penetrate within the tissue layer up to 780 ?m while Fe content TiO2 NPs samples showed the lowest rate of penetration up to 210 ?m after a 30 min time interval. � 2021 Author(s).en_US
dc.identifier.doi10.1063/5.0031385
dc.identifier.issn21583226
dc.identifier.urihttp://10.2.3.109/handle/32116/3638
dc.identifier.urlhttps://pubs.aip.org/adv/article/11/1/015023/1069518/Iron-content-titanium-dioxide-nanoparticles-as
dc.language.isoen_USen_US
dc.publisherAmerican Institute of Physics Inc.en_US
dc.subjectHigh resolution transmission electron microscopyen_US
dc.subjectIron oxidesen_US
dc.subjectNanoparticlesen_US
dc.subjectOptical tomographyen_US
dc.subjectOxide mineralsen_US
dc.subjectSol-gel processen_US
dc.subjectSol-gelsen_US
dc.subjectTiO2 nanoparticlesen_US
dc.subjectTissueen_US
dc.subjectTitanium dioxideen_US
dc.subjectTomographyen_US
dc.subjectX ray photoelectron spectroscopyen_US
dc.subjectContrast Enhancementen_US
dc.subjectContrast to noise ratioen_US
dc.subjectDiffuse reflectance spectroscopyen_US
dc.subjectNanoparticle (NPs)en_US
dc.subjectRate of penetrationen_US
dc.subjectScattering co-efficienten_US
dc.subjectSwept source optical coherence tomographiesen_US
dc.subjectTitanium dioxides (TiO2)en_US
dc.subjectTissue engineeringen_US
dc.titleIron content titanium dioxide nanoparticles as exogenous contrast agent for tissue imaging using swept-source optical coherence tomographyen_US
dc.title.journalAIP Advancesen_US
dc.typeArticleen_US
dc.type.accesstypeOpen Accessen_US

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