Rapid Arc-SBRT: Non-Invasive Immune Adjuvant for Advanced Stage Non-Small Cell Lung Carcinoma

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dc.contributor.authorChairmadurai, Arun
dc.contributor.authorJain, Sandeep K.
dc.contributor.authorJain, Aklank
dc.contributor.authorPrakash, Hridayesh
dc.date.accessioned2024-01-21T10:44:35Z
dc.date.accessioned2024-08-13T13:22:21Z
dc.date.available2024-01-21T10:44:35Z
dc.date.available2024-08-13T13:22:21Z
dc.date.issued2021-03-23T00:00:00
dc.description.abstractIn conjunction with radio-chemotherapy, pulmonary resection is recommended for early-stage non-small-cell lung carcinoma but not for advanced-stage NSCLC patients having high-grade metastatic lesions. In these cases, the rapid Arc-Stereotactic body radiotherapy (Ra-SBRT) technique offers a therapeutic advantage by delivering focal irradiation to metastatic lung lesions and reduces the bystander toxicity to normal tissues. We have previously demonstrated that Ra-SBRT ablates metastatic lesions and induces tumor immune rejection of metastatic tumors by promoting in situ programming of M2 TAM towards M1-TAM and infiltration of Siglec-8+ Eosinophils. Most interestingly, Ra SBRT has very low abscopal impact and spares normal tissues, which are the significant limitations with conventional radiotherapy. In view of this and the immune adjuvant potential of Ra SBRT, it promotes normalization of aberrant vasculature and inhibits the metastatic potential of NSCLC lesions. In view of this, we here propose that Ra-SBRT indeed represents an immunogenic approach for the effective management of advanced-stage NSCLC. � 2022 Bentham Science Publishers.en_US
dc.identifier.doi10.2174/1871520621666210322105641
dc.identifier.issn18715206
dc.identifier.urihttp://10.2.3.109/handle/32116/3798
dc.identifier.urlhttps://www.eurekaselect.com/192377/article
dc.language.isoen_USen_US
dc.publisherBentham Science Publishersen_US
dc.subjectImmune adjuvanten_US
dc.subjectLung canceren_US
dc.subjectMacrophage polarizationen_US
dc.subjectSBRTen_US
dc.subjectTumor therapyen_US
dc.titleRapid Arc-SBRT: Non-Invasive Immune Adjuvant for Advanced Stage Non-Small Cell Lung Carcinomaen_US
dc.title.journalAnti-Cancer Agents in Medicinal Chemistryen_US
dc.typeArticleen_US
dc.type.accesstypeClosed Accessen_US

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