Targeting mitochondrial bioenergetics as a promising therapeutic strategy in metabolic and neurodegenerative diseases

Simple item page
dc.contributor.authorBhatti, Gurjit Kaur
dc.contributor.authorGupta, Anshika
dc.contributor.authorPahwa, Paras
dc.contributor.authorKhullar, Naina
dc.contributor.authorSingh, Satwinder
dc.contributor.authorNavik, Umashanker
dc.contributor.authorKumar, Shashank
dc.contributor.authorMastana, Sarabjit Singh
dc.contributor.authorReddy, Arubala P.
dc.contributor.authorReddy, P. Hemachandra
dc.contributor.authorBhatti, Jasvinder Singh
dc.date.accessioned2024-01-21T10:48:39Z
dc.date.accessioned2024-08-14T05:05:58Z
dc.date.available2024-01-21T10:48:39Z
dc.date.available2024-08-14T05:05:58Z
dc.date.issued2022-05-11T00:00:00
dc.description.abstractMitochondria are the organelles that generate energy for the cells and act as biosynthetic and bioenergetic factories, vital for normal cell functioning and human health. Mitochondrial bioenergetics is considered an important measure to assess the pathogenesis of various diseases. Dysfunctional mitochondria affect or cause several conditions involving the most energy-intensive organs, including the brain, muscles, heart, and liver. This dysfunction may be attributed to an alteration in mitochondrial enzymes, increased oxidative stress, impairment of electron transport chain and oxidative phosphorylation, or mutations in mitochondrial DNA that leads to the pathophysiology of various pathological conditions, including neurological and metabolic disorders. The drugs or compounds targeting mitochondria are considered more effective and safer for treating these diseases. In this review, we make an effort to concise the available literature on mitochondrial bioenergetics in various conditions and the therapeutic potential of various drugs/compounds targeting mitochondrial bioenergetics in metabolic and neurodegenerative diseases. � 2022 Chang Gung Universityen_US
dc.identifier.doi10.1016/j.bj.2022.05.002
dc.identifier.issn23194170
dc.identifier.urihttp://10.2.3.109/handle/32116/3906
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S2319417022000749
dc.language.isoen_USen_US
dc.publisherElsevier B.V.en_US
dc.subjectAntioxidantsen_US
dc.subjectBioenergeticsen_US
dc.subjectElectron transport chainen_US
dc.subjectMitochondrial dysfunctionen_US
dc.subjectOxidative stressen_US
dc.titleTargeting mitochondrial bioenergetics as a promising therapeutic strategy in metabolic and neurodegenerative diseasesen_US
dc.title.journalBiomedical Journalen_US
dc.typeReviewen_US
dc.type.accesstypeOpen Accessen_US

Files

Collections

Computer Science And Technology - Research Publications