Glycine Catalyzed One-Pot Three-Component Synthesis of Structurally Diverse 2-Amino Substituted Pyran Annulated Heterocycles in Aqueous Ethanol under Refluxed Conditions

Simple item page
dc.contributor.authorBanerjee, Bubun
dc.contributor.authorKaur, Manmeet
dc.contributor.authorSharma, Aditi
dc.contributor.authorSingh, Arvind
dc.contributor.authorPriya, Anu
dc.contributor.authorGupta, Vivek Kumar
dc.contributor.authorJaitak, Vikas
dc.date.accessioned2024-01-21T10:38:29Z
dc.date.accessioned2024-08-13T12:05:26Z
dc.date.available2024-01-21T10:38:29Z
dc.date.available2024-08-13T12:05:26Z
dc.date.issued2022-12-14T00:00:00
dc.description.abstractIntroduction: A facile, convenient and general method has been developed for the one-pot three-component synthesis of structurally diverse 2-amino pyran annulated heterocycles from the reactions of aromatic aldehydes, malononitrile and various C-H activated acids in the presence of a catalytic amount of glycine as an efficient metal-free organocatalyst in aqueous ethanol under refluxed conditions. Methods: Using this developed protocol, we were able to synthesize a series of structurally diverse 2-amino pyran derivatives viz., 2-amino-4,5-dihydropyrano[3,2-c]chromenes, 2-amino-4,5-dihydropyrano [4,3-b]pyrans, 2-amino-5,6,7,8-tetrahydro-4H-chromenes, 2'-amino-2,5'-dioxo-5'H-spiro[indoline-3,4'-pyrano [3,2-c]chromene]-3'-carbonitrile and 2'-amino-1,3,5'-trioxo-1,3-dihydro-5'H-spiro[indene-2,4'-pyrano[3,2-c]chromene]-3'-carbonitrile in excellent yields. Result: Synthesis of biologically promising pyrans and spiropyrans, high atom economy, excellent yields, use of metal-free catalyst, less toxic solvents, no chromatographic column purifications, multiple carbon-carbon and carbon-heteroatom bond formations are some of the major advantages of this newly developed protocol. Conclusion: In conclusion, we have developed a simple, convenient, and efficient method for the synthesis of a series of structurally diverse 2-amino pyran annulated heterocyclic derivatives. � 2022 Bentham Science Publishers.en_US
dc.identifier.doi10.2174/2213346110666221212152202
dc.identifier.issn22133461
dc.identifier.urihttp://10.2.3.109/handle/32116/3585
dc.identifier.urlhttps://www.eurekaselect.com/211878/article
dc.language.isoen_USen_US
dc.publisherBentham Science Publishersen_US
dc.subject2-amino-spiro-pyransen_US
dc.subjectGlycineen_US
dc.subjectmulticomponent reactionsen_US
dc.subjectorganocatalysisen_US
dc.subjectpyran annulated heterocyclesen_US
dc.subjectsustainable developmentsen_US
dc.titleGlycine Catalyzed One-Pot Three-Component Synthesis of Structurally Diverse 2-Amino Substituted Pyran Annulated Heterocycles in Aqueous Ethanol under Refluxed Conditionsen_US
dc.title.journalCurrent Green Chemistryen_US
dc.typeArticleen_US
dc.type.accesstypeClosed Accessen_US

Files

Collections

Pharmaceutical Sciences and Natural Products - Research Publications