Maternal candidate gene variants, epigenetic factors, and susceptibility to idiopathic recurrent pregnancy loss: A systematic review

dc.contributor.authorKaur, Mandeep
dc.contributor.authorKaur, Rajinder
dc.contributor.authorChhabra, Kiran
dc.contributor.authorKhetarpal, Preeti
dc.date.accessioned2024-01-21T10:54:11Z
dc.date.accessioned2024-08-14T07:40:55Z
dc.date.available2024-01-21T10:54:11Z
dc.date.available2024-08-14T07:40:55Z
dc.date.issued2023-01-30T00:00:00
dc.description.abstractBackground: Recurrent pregnancy loss is defined as the loss of two or more pregnancies and is a distressing condition for couples. Objective: To investigate the relationship between variants in the candidate susceptibility genes and epigenetic factors to identify risk factors for idiopathic recurrent pregnancy loss (iRPL). Search Strategy: A systematic literature search was performed using PubMed, Google Scholar, ScienceDirect, and Scopus databases. Insilico analysis was carried out using ShinyGO and STRING software. Selection Criteria: Research papers examining the association between variations in genetic and epigenetic factors and iRPL. Data Collection and Analysis: Data were independently extracted by two authors. Main Results: In total, 83 research papers were finally selected for the present study. Among all the genes involved in the pathogenesis of recurrent pregnancy loss, polymorphisms in IL superfamily genes, VEGF, ESR, and MTHFR were the most investigated. Conclusion: Polymorphisms in angiogenesis, immune tolerance, and thrombophilia pathway genes, which occur independently or synergistically, may lead to various complications during fetal development. Identification of multi-allele risk variants and epigenetic factors in women will be helpful in the identification of high-risk pregnancies. Prospero Registration Number: Prospero CRD42021287315. � 2023 International Federation of Gynecology and Obstetrics.en_US
dc.identifier.doi10.1002/ijgo.14701
dc.identifier.issn207292
dc.identifier.urihttps://kr.cup.edu.in/handle/32116/4239
dc.identifier.urlhttps://obgyn.onlinelibrary.wiley.com/doi/10.1002/ijgo.14701
dc.language.isoen_USen_US
dc.publisherJohn Wiley and Sons Ltden_US
dc.subjectCandidate gene variantsen_US
dc.subjectEpigenetic factorsen_US
dc.subjectIdiopathic recurrent pregnancy lossen_US
dc.subjectMaternal factorsen_US
dc.subjectSystematic reviewen_US
dc.titleMaternal candidate gene variants, epigenetic factors, and susceptibility to idiopathic recurrent pregnancy loss: A systematic reviewen_US
dc.title.journalInternational Journal of Gynecology and Obstetricsen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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