A cascade A3 coupling strategy towards the regioselective synthesis of ?-carboline N-fused pyrrole derivatives with pyridine tethers
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Date
2022-12-01T00:00:00
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Publisher
Royal Society of Chemistry
Abstract
A potential three component reaction strategy has been devised to generate nature inspired ?-carboline N-fused pyrroles containing pyridine tethers. These scaffolds were afforded in high yields via a one-pot cascade regioselective reaction of diverse Kumujian C, 2-aminopyridines and alkyne derivatives under Cu(ii)-catalysis. A library of 32 novel indolizino[8,7-b]indole derivatives with pyridine tethers has been developed. The current protocol offers excellent regioselectivity, high atom-economy and significant structural diversity. � 2023 The Royal Society of Chemistry.
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Keywords
Biomimetic processes, Copper compounds, Regioselectivity, Scaffolds, Synthesis (chemical), Tetherlines, alkyne derivative, beta carboline derivative, copper, indole derivative, indolizino[8,7 b]indole derivative, pyridine, pyrrole derivative, unclassified drug, 2-Aminopyridine, Fused pyrrole, Higher yield, One pot, Pyrrole derivatives, Reaction strategies, Regioselective reactions, Regioselective synthesis, Three component reactions, ?-carboline, Article, catalysis, chemical structure, cross coupling reaction, economic aspect, one pot synthesis, regioselectivity, synthesis, Pyridine