Dysregulated autophagy: A key player in the pathophysiology of type 2 diabetes and its complications

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dc.contributor.authorSehrawat, Abhishek
dc.contributor.authorMishra, Jayapriya
dc.contributor.authorMastana, Sarabjit Singh
dc.contributor.authorNavik, Umashanker
dc.contributor.authorBhatti, Gurjit Kaur
dc.contributor.authorReddy, P. Hemachandra
dc.contributor.authorBhatti, Jasvinder Singh
dc.date.accessioned2024-01-21T10:55:10Z
dc.date.accessioned2024-08-14T07:44:24Z
dc.date.available2024-01-21T10:55:10Z
dc.date.available2024-08-14T07:44:24Z
dc.date.issued2023-02-14T00:00:00
dc.description.abstractAutophagy is essential in regulating the turnover of macromolecules via removing damaged organelles, misfolded proteins in various tissues, including liver, skeletal muscles, and adipose tissue to maintain the cellular homeostasis. In these tissues, a specific type of autophagy maintains the accumulation of lipid droplets which is directly related to obesity and the development of insulin resistance. It appears to play a protective role in a normal physiological environment by eliminating the invading pathogens, protein aggregates, and damaged organelles and generating energy and new building blocks by recycling the cellular components. Ageing is also a crucial modulator of autophagy process. During stress conditions involving nutrient deficiency, lipids excess, hypoxia etc., autophagy serves as a pro-survival mechanism by recycling the free amino acids to maintain the synthesis of proteins. The dysregulated autophagy has been found in several ageing associated diseases including type 2 diabetes (T2DM), cancer, and neurodegenerative disorders. So, targeting autophagy can be a promising therapeutic strategy against the progression to diabetes related complications. Our article provides a comprehensive outline of understanding of the autophagy process, including its types, mechanisms, regulation, and role in the pathophysiology of T2DM and related complications. We also explored the significance of autophagy in the homeostasis of ?-cells, insulin resistance (IR), clearance of protein aggregates such as islet amyloid polypeptide, and various insulin-sensitive tissues. This will further pave the way for developing novel therapeutic strategies for diabetes-related complications. � 2023 Elsevier B.V.en_US
dc.identifier.doi10.1016/j.bbadis.2023.166666
dc.identifier.issn9254439
dc.identifier.urihttp://10.2.3.109/handle/32116/4360
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S0925443923000327
dc.language.isoen_USen_US
dc.publisherElsevier B.V.en_US
dc.subjectAutophagyen_US
dc.subjectER stressen_US
dc.subjectInsulin resistanceen_US
dc.subjectmicroRNAsen_US
dc.subjectType 2 diabetesen_US
dc.titleDysregulated autophagy: A key player in the pathophysiology of type 2 diabetes and its complicationsen_US
dc.title.journalBiochimica et Biophysica Acta - Molecular Basis of Diseaseen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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