In Silico Study of the Structural Disruption of 14?-demethylase Induced by the Binding of Terminalia chebula Constituents

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dc.contributor.authorRani, Nidhi
dc.contributor.authorSingh, Randhir
dc.contributor.authorKumar, Praveen
dc.contributor.authorVerma, Nitin
dc.date.accessioned2024-01-21T10:55:16Z
dc.date.accessioned2024-08-14T07:44:15Z
dc.date.available2024-01-21T10:55:16Z
dc.date.available2024-08-14T07:44:15Z
dc.date.issued2023-07-11T00:00:00
dc.description.abstractBackground: Since ancient times, medicinal plants have been in use in medicine and daily life. Objective: To develop new antifungal compounds with low toxicity and high efficacy followed by high bioavailability, the constituents of Terminalia chebula were studied. Methods: The chemical constituents of the plant were evaluated for antifungal potential via Molergo Virtual Docker against the enzyme 14?-demethylase. Results: The study depicted that tannins exhibited very good potential against the enzyme and could be used further for lead development. Conclusion: The study revealed that the plant possessed various constituents with potential antifungal properties and low toxicity. � 2024 Bentham Science Publishers.en_US
dc.identifier.doi10.2174/2215083810666230710122114
dc.identifier.issn22150838
dc.identifier.urihttp://10.2.3.109/handle/32116/4387
dc.identifier.urlhttps://www.eurekaselect.com/218590/article
dc.language.isoen_USen_US
dc.publisherBentham Science Publishersen_US
dc.subject14?-demethylaseen_US
dc.subjectAntifungalen_US
dc.subjectantifungal compoundsen_US
dc.subjectmolecular dockingen_US
dc.subjecttanninsen_US
dc.subjectterminaliaen_US
dc.titleIn Silico Study of the Structural Disruption of 14?-demethylase Induced by the Binding of Terminalia chebula Constituentsen_US
dc.title.journalCurrent Traditional Medicineen_US
dc.typeArticleen_US
dc.type.accesstypeClosed Accessen_US

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