Targeting Mitochondria as a Novel Disease-Modifying Therapeutic Strategy in Cancer
| dc.contributor.author | Bhatti, Gurjit Kaur | |
| dc.contributor.author | Pahwa, Paras | |
| dc.contributor.author | Gupta, Anshika | |
| dc.contributor.author | Navik, Uma Shanker | |
| dc.contributor.author | Reddy, P. Hemachandra | |
| dc.contributor.author | Bhatti, Jasvinder Singh | |
| dc.date.accessioned | 2024-01-21T10:55:00Z | |
| dc.date.accessioned | 2024-08-14T07:44:18Z | |
| dc.date.available | 2024-01-21T10:55:00Z | |
| dc.date.available | 2024-08-14T07:44:18Z | |
| dc.date.issued | 2022-01-31T00:00:00 | |
| dc.description.abstract | Mitochondria are important for the metabolism of energy, regulation of apoptosis and cell signaling. Overproduction of reactive oxidation species (ROS) in mitochondria is one of the indications of cancer cells; moreover, this boosts the proliferation of cancerous cells by causing genomic instability and altering gene expressions. Mitochondrial and nuclear DNA mutations, caused by oxidative damage which impairs the mechanism of oxidative phosphorylation, can lead to more mitochondrial ROS output, genome instability, and the development of the cancer. Classic approach to target mitochondria of cancerous cells with novel-targeted therapeutics helps in targeting the mitochondrial apoptotic proteins and changing energy metabolism. Key benefit of selective drug delivery is it reduces the toxicity of drug and increases specificity. Better understanding of mitochondrial role in tumor growth will help to design more therapeutic agents with better selectivity. � Springer Nature Singapore Pte Ltd. 2022. | en_US |
| dc.identifier.doi | 10.1007/978-981-15-9411-3_21 | |
| dc.identifier.isbn | 9789811594113 | |
| dc.identifier.isbn | 9789811594106 | |
| dc.identifier.uri | http://10.2.3.109/handle/32116/4308 | |
| dc.identifier.url | https://link.springer.com/10.1007/978-981-15-9411-3_21 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Springer Nature | en_US |
| dc.subject | Bioenergetic therapy | en_US |
| dc.subject | Cancer | en_US |
| dc.subject | Mitochondria | en_US |
| dc.subject | Mitochondrial medicine | en_US |
| dc.subject | ROS | en_US |
| dc.subject | Targeted drug delivery | en_US |
| dc.title | Targeting Mitochondria as a Novel Disease-Modifying Therapeutic Strategy in Cancer | en_US |
| dc.title.journal | Handbook of Oxidative Stress in Cancer: Mechanistic Aspects | en_US |
| dc.type | Book chapter | en_US |
| dc.type.accesstype | Closed Access | en_US |