Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes
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Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
Nature Publishing Group
Abstract
Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this study, we conducted a meta-analysis of GWAS for T2D in the Japanese population. Combined data from discovery and subsequent validation analyses (23,399 T2D cases and 31,722 controls) identify 7 new loci with genome-wide significance (P<5 ? 10-8), rs1116357 near CCDC85A, rs147538848 in FAM60A, rs1575972 near DMRTA1, rs9309245 near ASB3, rs67156297 near ATP8B2, rs7107784 near MIR4686 and rs67839313 near INAFM2. Of these, the association of 4 loci with T2D is replicated in multi-ethnic populations other than Japanese (up to 65,936 T2Ds and 158,030 controls, P<0.007). These results indicate that expansion of single ethnic GWAS is still useful to identify novel susceptibility loci to complex traits not only for ethnicity-specific loci but also for common loci across different ethnicities. ? 2016, Nature Publishing Group. All rights reserved.
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Keywords
Diabetes, Ethnic Group, Genetic Analysis, Health Risk, Heritability, Meta-Analysis Asb3 Gene, Atp8B2 Gene, Ccdc85A Gene, Dmrta1 Gene, Ethnic Group, Fam60A Gene, Gene, Gene Locus, Genetic Association, Genetic Susceptibility, Genotype, Human, Inafm2 Gene, Japanese (People), Major Clinical Study, Meta Analysis, Mir4686 Gene, Non Insulin Dependent Diabetes Mellitus, Single Nucleotide Polymorphism, Asian Continental Ancestry Group, Case Control Study, Genetic Predisposition, Genetics, Genom
Citation
Imamura, M., Takahashi, A., Yamauchi, T., Hara, K., Yasuda, K., Grarup, N., . . . Kadowaki, T. (2016). Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. Nature Communications, 7. doi: 10.1038/ncomms10531