Apoptosis and Pharmacological Therapies for Targeting Thereof for Cancer Therapeutics

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dc.contributor.authorSingh, Vishakha
dc.contributor.authorKhurana, Amit
dc.contributor.authorNavik, Umashanker
dc.contributor.authorAllawadhi, Prince
dc.contributor.authorBharani, Kala Kumar
dc.contributor.authorWeiskirchen, Ralf
dc.date.accessioned2024-01-21T10:55:02Z
dc.date.accessioned2024-08-14T07:44:19Z
dc.date.available2024-01-21T10:55:02Z
dc.date.available2024-08-14T07:44:19Z
dc.date.issued2022-04-08T00:00:00
dc.description.abstractApoptosis is an evolutionarily conserved sequential process of cell death to maintain a homeostatic balance between cell formation and cell death. It is a vital process for normal eukaryotic development as it contributes to the renewal of cells and tissues. Further, it plays a crucial role in the elimination of unnecessary cells through phagocytosis and prevents undesirable immune responses. Apoptosis is regulated by a complex signaling mechanism, which is driven by interactions among several protein families such as caspases, inhibitors of apoptosis proteins, B-cell lymphoma 2 (BCL-2) family proteins, and several other proteases such as perforins and granzyme. The signaling pathway consists of both pro-apoptotic and pro-survival members, which stabilize the selection of cellular survival or death. However, any aberration in this pathway can lead to abnormal cell proliferation, ultimately leading to the development of cancer, autoimmune disorders, etc. This review aims to elaborate on apoptotic signaling pathways and mechanisms, interacting members involved in signaling, and how apoptosis is associated with carcinogenesis, along with insights into targeting apoptosis for disease resolution. � 2022 by the authors.en_US
dc.identifier.doi10.3390/sci4020015
dc.identifier.issn24134155
dc.identifier.urihttp://10.2.3.109/handle/32116/4317
dc.identifier.urlhttps://www.mdpi.com/2413-4155/4/2/15
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.subjectapoptosisen_US
dc.subjectBCL-2en_US
dc.subjectcarcinogenesisen_US
dc.subjectcaspaseen_US
dc.subjectextrinsic pathwayen_US
dc.subjectinhibitorsen_US
dc.subjectintrinsic pathwayen_US
dc.subjectsignalingen_US
dc.subjecttherapyen_US
dc.subjecttumor suppressoren_US
dc.titleApoptosis and Pharmacological Therapies for Targeting Thereof for Cancer Therapeuticsen_US
dc.title.journalScien_US
dc.typeReviewen_US
dc.type.accesstypeOpen Accessen_US

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