Drug-metabolizing enzymes: role in drug resistance in cancer

dc.contributor.authorKaur, G
dc.contributor.authorGupta, S.K
dc.contributor.authorSingh, P
dc.contributor.authorAli, V
dc.contributor.authorKumar, V
dc.contributor.authorVerma, M.
dc.date.accessioned2020-07-16T07:41:58Z
dc.date.accessioned2024-08-13T10:34:53Z
dc.date.available2020-07-16T07:41:58Z
dc.date.available2024-08-13T10:34:53Z
dc.date.issued2020
dc.description.abstractAlthough continuous researches are going on for the discovery of new chemotherapeutic agents, resistance to these anticancer agents has made it really difficult to reach the fruitful results. There are many causes for this resistance that are being studied by the researchers across the world, but still, success is far because there are several factors that are going along unattended or have been studied less. Drug-metabolizing enzymes (DMEs) are one of these factors, on which less study has been conducted. DMEs include Phase I and Phase II enzymes. Cytochrome P450s (CYPs) are major Phase I enzymes while glutathione-S-transferases (GSTs), UDP-glucuronosyltransferases (UGTs), dihydropyrimidine dehydrogenases are the major enzymes belonging to the Phase II enzymes. These enzymes play an important role in detoxification of the xenobiotics as well as the metabolism of drugs, depending upon the tissue in which they are expressed. When present in tumorous tissues, they cause resistance by metabolizing the drugs and rendering them inactive. In this review, the role of these various enzymes in anticancer drug metabolism and the possibilities for overcoming the resistance have been discussed. � 2020, Federaci�n de Sociedades Espa�olas de Oncolog�a (FESEO).en_US
dc.identifier.doi10.1007/s12094-020-02325-7
dc.identifier.issn1699048X
dc.identifier.urihttps://kr.cup.edu.in/handle/32116/2686
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs12094-020-02325-7
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.subjectDME inhibitorsen_US
dc.subjectDrug metabolismen_US
dc.subjectDrug resistanceen_US
dc.subjectDrug-metabolizing enzymes (DMEs)en_US
dc.subjectProdrugsen_US
dc.titleDrug-metabolizing enzymes: role in drug resistance in canceren_US
dc.title.journalClinical and Translational Oncologyen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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