Aldose Reductase: a cause and a potential target for the treatment of diabetic complications

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dc.contributor.authorThakur, Sapna
dc.contributor.authorGupta, Sonu Kumar
dc.contributor.authorAli, Villayat
dc.contributor.authorSingh, Priyanka
dc.contributor.authorVerma, Malkhey
dc.date.accessioned2024-01-16T14:23:09Z
dc.date.accessioned2024-08-13T10:34:07Z
dc.date.available2024-01-16T14:23:09Z
dc.date.available2024-08-13T10:34:07Z
dc.date.issued2021-07-19T00:00:00
dc.description.abstractDiabetes mellitus, a disorder of metabolism, results in the elevation of glucose level in the blood. In this hyperglycaemic condition, aldose reductase overexpresses and leads to further complications of diabetes through the polyol pathway. Glucose metabolism-related disorders are the accumulation of sorbitol, overproduction of NADH and fructose, reduction in NAD+, and excessive NADPH usage, leading to diabetic pathogenesis and its complications such as�retinopathy, neuropathy, and nephropathy. Accumulation of sorbitol results in the alteration of osmotic pressure and leads to osmotic stress. The overproduction of NADH causes an increase in reactive oxygen species production which leads to oxidative stress. The overproduction of fructose causes cell death and non-alcoholic fatty liver disease. Apart from these disorders, many other complications have also been discussed in the literature. Therefore, the article overviews the aldose reductase as the causative agent and a potential target for the treatment of diabetic complications. So, aldose reductase inhibitors have gained much importance worldwide right now. Several inhibitors, like derivatives of carboxylic acid, spirohydantoin, phenolic derivatives, etc. could prevent diabetic complications are discussed in this article. � 2021, The Pharmaceutical Society of Korea.en_US
dc.identifier.doi10.1007/s12272-021-01343-5
dc.identifier.issn2536269
dc.identifier.urihttps://doi.org/10.1007/s12272-021-01343-5
dc.identifier.urihttp://10.2.3.109/handle/32116/2857
dc.language.isoen_USen_US
dc.publisherPharmaceutical Society of Koreaen_US
dc.subjectAldose reductaseen_US
dc.subjectAldose reductase inhibitorsen_US
dc.subjectDiabetic complicationsen_US
dc.subjectHyperglycaemic conditionsen_US
dc.subjectSorbitol dehydrogenaseen_US
dc.titleAldose Reductase: a cause and a potential target for the treatment of diabetic complicationsen_US
dc.title.journalArchives of Pharmacal Researchen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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