Design, synthesis, and unraveling the antibacterial and antibiofilm potential of 2-azidobenzothiazoles: insights from a comprehensive in vitro study

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dc.contributor.authorQadir, Tanzeela
dc.contributor.authorKanth, Saadat A.
dc.contributor.authorAasif, Mohammad
dc.contributor.authorFadul, Abdalla N.
dc.contributor.authorYatoo, Gulam N.
dc.contributor.authorJangid, Kailash
dc.contributor.authorMir, Mushtaq A.
dc.contributor.authorShah, Wajahat A.
dc.contributor.authorSharma, Praveen K.
dc.date.accessioned2024-01-21T10:33:11Z
dc.date.accessioned2024-08-13T11:16:22Z
dc.date.available2024-01-21T10:33:11Z
dc.date.available2024-08-13T11:16:22Z
dc.date.issued2023-09-07T00:00:00
dc.description.abstractThe present study reports the synthesis of 2-azidobenzothiazoles from substituted 2-aminobenzothiazoles using sodium nitrite and sodium azide under mild conditions. All the synthesized compounds were examined for their antibacterial activity against Gram (+) bacteria, Staphylococcus aureus (ATCC 25923), Enterococcus faecalis (ATCC 51299), Bacillus cereus (ATCC 10876) and Gram (?) bacteria, Escherichia coli (ATCC 10536), Pseudomonas aeruginosa (ATCC 10145), Klebsiella pneumonia (ATCC BAA-2146)and clinical isolates of Gram (+) Methicillin Resistant S. aureus (MRSA) and Multi Drug Resistant E. coli. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values by broth dilution method revealed that compound 2d exhibited significant antibacterial potential against E. faecalis and S. aureus with MIC of 8�?g/mL, while other synthesized compounds had only moderate effects against all the tested species. The compound significantly inhibited the biofilm formation of the bacterial strains below its MIC. The selective cytotoxicity of Compound 2d towards bacterial cells was evidenced on extended exposure of Human Embryonic Kidney-293 cell line to higher concentrations of the compound. Hence, the present study confirmed that compound 2d can be a potential drug candidate for future development as an antibacterial drug. Copyright � 2023 Qadir, Kanth, Aasif, Fadul, Yatoo, Jangid, Mir, Shah and Sharma.en_US
dc.identifier.doi10.3389/fchem.2023.1264747
dc.identifier.issn22962646
dc.identifier.urihttp://10.2.3.109/handle/32116/3289
dc.identifier.urlhttps://www.frontiersin.org/articles/10.3389/fchem.2023.1264747/full
dc.language.isoen_USen_US
dc.publisherFrontiers Media SAen_US
dc.subject2-azidobenzothiazolesen_US
dc.subjectantibacterial activityen_US
dc.subjectbenzothiazolesen_US
dc.subjectbiofilm inhibition assayen_US
dc.subjectcytotoxicity assayen_US
dc.subjectsynthesisen_US
dc.titleDesign, synthesis, and unraveling the antibacterial and antibiofilm potential of 2-azidobenzothiazoles: insights from a comprehensive in vitro studyen_US
dc.title.journalFrontiers in Chemistryen_US
dc.typeArticleen_US
dc.type.accesstypeOpen Accessen_US

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