Copper-Catalyzed C(sp3)? Functionalization and Annulation of 2-Bromoaryl Oximes with Active Methylene Compounds towards Synthesis of Isoquinoline N-Oxides
| dc.contributor.author | Patel, Chandresh K. | |
| dc.contributor.author | Gujjarappa, Raghuram | |
| dc.contributor.author | Kant, Kamal | |
| dc.contributor.author | Ghanta, Susanta | |
| dc.contributor.author | Singh, Virender | |
| dc.contributor.author | Kabi, Arup K. | |
| dc.contributor.author | Al-Zaqri, Nabil | |
| dc.contributor.author | Malakar, Chandi C. | |
| dc.date.accessioned | 2024-01-21T10:33:08Z | |
| dc.date.accessioned | 2024-08-13T11:16:20Z | |
| dc.date.available | 2024-01-21T10:33:08Z | |
| dc.date.available | 2024-08-13T11:16:20Z | |
| dc.date.issued | 2023-06-09T00:00:00 | |
| dc.description.abstract | The established process proceeds through copper (II)-catalyzed C(sp3)? functionalization of ?-diketones/?-ketoesters with 2-bromobenzaldehyde oximes followed by the intramolecular cyclization of in situ generated acylated intermediates to deliver isoquinoline N-oxides. The copper(II) acetate catalyzed C?H functionalization showed maximum efficacy at 60 �C in methanol/toluene as solvent. The described reaction conditions were applicable over a wide range of substrates with a variety of functional groups to yield isoquinoline N-oxides in yields up to 85%. The developed approach was further elucidated by means of control experiments and DFT calculations. � 2023 Wiley-VCH GmbH. | en_US |
| dc.identifier.doi | 10.1002/adsc.202300217 | |
| dc.identifier.issn | 16154150 | |
| dc.identifier.uri | https://kr.cup.edu.in/handle/32116/3277 | |
| dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1002/adsc.202300217 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | John Wiley and Sons Inc | en_US |
| dc.subject | Active methylene compounds | en_US |
| dc.subject | C(sp<sup>3</sup>)? activation | en_US |
| dc.subject | Copper catalysis | en_US |
| dc.subject | Isoquinoline N-oxide | en_US |
| dc.subject | trans-esterification | en_US |
| dc.title | Copper-Catalyzed C(sp3)? Functionalization and Annulation of 2-Bromoaryl Oximes with Active Methylene Compounds towards Synthesis of Isoquinoline N-Oxides | en_US |
| dc.title.journal | Advanced Synthesis and Catalysis | en_US |
| dc.type | Article | en_US |
| dc.type.accesstype | Closed Access | en_US |