Ganoderic acid targeting multiple receptors in cancer: in silico and in vitro study

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dc.contributor.authorGill, Balraj Singh
dc.contributor.authorNavgeet
dc.contributor.authorKumar, Sanjeev
dc.contributor.authorGill, B.S.
dc.contributor.authorNavgeet, Kumar, S.
dc.date.accessioned2017-12-29T04:39:59Z
dc.date.accessioned2024-08-13T11:03:24Z
dc.date.available2017-12-29T04:39:59Z
dc.date.available2024-08-13T11:03:24Z
dc.date.issued2016
dc.description.abstractReceptor tyrosine kinases (RTKs) are transmembrane high-affinity surface receptors responsible for cell migration, adhesion, apoptosis, metabolism, and cell proliferation activities in various cancers. Minute aberration in the RTK signaling modulates the downstream signaling pathways that results in cancer. Ganoderic acid is a triterpene isolated from Ganoderma lucidum, which is renowned for its therapeutics effect, especially in cancer. The present study discusses receptor-based molecular docking of insulin receptor (IR), insulin-like growth factor receptor 1 (IGFR-1), vascular endothelial growth factor receptor-1 (VEGFR-1), vascular endothelial growth factor receptor-2 (VEGFR-2), and estrogen receptor (ER) with 50 isoforms of ganoderic acid along with natural inhibitors. These receptors were assessed for toxicity (ADMET) by using Maestro 9.6 (Schr?dinger Inc). The calculated docking free energy yielded an excellent dock score for the ganoderic acid when docked with proteins IR, IGFR-1, VEGFR-1, VEGFR-2, and ER, suggesting its potential in combating cancer. Protein?ligand profile highlighted the binding interactions comprising lipophilic, hydrogen bonding, pi-pi stacking interactions, and noncovalent bonding which play a pivotal role in targeting cancer. In silico studies revealed structure of ganoderic acid A as best isoforms among 50 isoforms which exhibits biological activity in liver cancer cells. Ganoderic acids A significantly decrease the viability, proliferation, and oxidative stress in a dose-dependent manner in liver cancer cells. ? 2016, International Society of Oncology and BioMarkers (ISOBM).en_US
dc.identifier.citationGill, B. S., Navgeet, & Kumar, S. (2016). Ganoderic acid targeting multiple receptors in cancer: in silico and in vitro study. Tumor Biology, 37(10), 14271-14290. doi: 10.1007/s13277-016-5291-8en_US
dc.identifier.doi10.1007/s13277-016-5291-8
dc.identifier.issn10104283
dc.identifier.urihttp://10.2.3.109/handle/32116/397
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs13277-016-5291-8
dc.language.isoenen_US
dc.publisherSpringer Netherlandsen_US
dc.subjectGanoderic Aciden_US
dc.subjectCanceren_US
dc.subjectReceptor Tyrosine Kinaseen_US
dc.subjectMolecular Dockingen_US
dc.subjectOxidative Stressen_US
dc.titleGanoderic acid targeting multiple receptors in cancer: in silico and in vitro studyen_US
dc.title.journalTumor Biology
dc.typeArticleen_US

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