Boron in cancer therapeutics: An overview

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dc.contributor.authorKulkarni, Swanand
dc.contributor.authorBhandary, Dyuti
dc.contributor.authorSingh, Yogesh
dc.contributor.authorMonga, Vikramdeep
dc.contributor.authorThareja, Suresh
dc.date.accessioned2024-01-21T10:38:38Z
dc.date.accessioned2024-08-13T12:05:35Z
dc.date.available2024-01-21T10:38:38Z
dc.date.available2024-08-13T12:05:35Z
dc.date.issued2023-10-17T00:00:00
dc.description.abstractBoron has become a crucial weapon in anticancer research due to its significant intervention in cell proliferation. Being an excellent bio-isosteric replacement of carbon, it has modulated the anticancer efficacy of various molecules in the development pipeline. It has elicited promising results through interactions with various therapeutic targets such as HIF-1?, steroid sulfatase, arginase, proteasome, etc. Since boron liberates alpha particles, it has a wide-scale application in Boron Neutron Capture therapy (BNCT), a radiotherapy that demonstrates selectivity towards cancer cells due to high boron uptake capacity. Significant advances in the medicinal chemistry of boronated compounds, such as boronated sugars, natural/unnatural amino acids, boronated DNA binders, etc., have been reported over the past few years as BNCT agents. In addition, boronated nanoparticles have assisted the field of bio-nano medicines by their usage in radiotherapy. This review exclusively focuses on the medicinal chemistry aspects, radiotherapeutic, and chemotherapeutic aspects of boron in cancer therapeutics. Emphasis is also given on the mechanism of action along with advantages over conventional therapies. � 2023 Elsevier Inc.en_US
dc.identifier.doi10.1016/j.pharmthera.2023.108548
dc.identifier.issn1637258
dc.identifier.urihttp://10.2.3.109/handle/32116/3623
dc.identifier.urlhttps://linkinghub.elsevier.com/retrieve/pii/S0163725823002127
dc.language.isoen_USen_US
dc.publisherElsevier Inc.en_US
dc.subjectAnticanceren_US
dc.subjectArginaseen_US
dc.subjectBoronen_US
dc.subjectBoron neutron capture therapyen_US
dc.subjectHIF-1?en_US
dc.subjectProstateen_US
dc.subjectProteasomeen_US
dc.subjectSpecific antigenen_US
dc.subjectSteroid sulfataseen_US
dc.titleBoron in cancer therapeutics: An overviewen_US
dc.title.journalPharmacology and Therapeuticsen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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