Establishing molecular signatures of stroke focusing on omic approaches: a narrative review

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dc.contributor.authorLudhiadch, A
dc.contributor.authorVasudeva, K
dc.contributor.authorMunshi, A.
dc.date.accessioned2020-07-16T07:41:58Z
dc.date.accessioned2024-08-14T07:40:38Z
dc.date.available2020-07-16T07:41:58Z
dc.date.available2024-08-14T07:40:38Z
dc.date.issued2020
dc.description.abstractStroke or �brain attack� is considered to be the major cause of mortality and morbidity worldwide after myocardial infraction. Inspite of the years of research and clinical practice, the pathogenesis of stroke still remains incompletely understood. Omics approaches not only enable the description of a huge number of molecular platforms but also have a potential to recognize new factors associated with various complex disorders including stroke. The most significant development among all other omics technologies over the recent years has been seen by genomics which is a powerful tool for exploring the genetic architecture of stroke. Genomics has decisively established itself in stroke research and by now wealth of data has been generated providing new insights into the physiology and pathophysiology of stroke. However, the efficacy of genomic data is restricted to risk prediction only. Omics approaches not only enable the description of a huge number of molecular platforms but also have a potential to recognize new factors associated with various complex disorders including stroke. The data generated by omics technologies enables clinicians to provide detailed insight into the makeup of stroke in individual patients, which will further help in developing diagnostic procedures to direct therapies. Present review has been compiled with an aim to understand the potential of integrated omics approach to help in characterization of mechanisms leading to stroke, to predict the patient risk of getting stroke by analyzing signature biomarkers and to develop targeted therapeutic strategies. � 2020, � 2020 Informa UK Limited, trading as Taylor & Francis Group.en_US
dc.identifier.doi10.1080/00207454.2020.1732964
dc.identifier.issn207454
dc.identifier.urihttp://10.2.3.109/handle/32116/2687
dc.identifier.urlhttps://www.tandfonline.com/doi/abs/10.1080/00207454.2020.1732964?journalCode=ines20
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltden_US
dc.subjectgenomicsen_US
dc.subjectGWASen_US
dc.subjectIschemic strokeen_US
dc.subjectstroke treatmenten_US
dc.titleEstablishing molecular signatures of stroke focusing on omic approaches: a narrative reviewen_US
dc.title.journalInternational Journal of Neuroscienceen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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