Metal-Free Direct Access to N-Sulfonyl Amidines from Sulfonamides and Secondary Amines Involving Tandem C-N Bond Formations

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dc.contributor.authorNishad, Chandra Shekhar
dc.contributor.authorHaldar, Krishna Kanta
dc.contributor.authorBanerjee, Biplab
dc.date.accessioned2024-01-21T10:33:02Z
dc.date.accessioned2024-08-13T11:16:45Z
dc.date.available2024-01-21T10:33:02Z
dc.date.available2024-08-13T11:16:45Z
dc.date.issued2022-08-17T00:00:00
dc.description.abstractWe report a mild and efficient metal-free one-pot procedure for the synthesis of N-sulfonyl amidines via the direct reaction of sulfonamides with secondary amines without using any additives. A wide range of substrates with variety of functional groups is well tolerated under the reaction conditions. Preliminary mechanistic studies indicate that the secondary amine plays a dual role as a C1 source of the amidine group and an aminating agent. Synthetic utility of this method is shown in the late-stage functionalization of drug molecules on the gram scale. � 2022 American Chemical Society.en_US
dc.identifier.doi10.1021/acs.joc.2c01292
dc.identifier.issn223263
dc.identifier.urihttp://10.2.3.109/handle/32116/3249
dc.identifier.urlhttps://pubs.acs.org/doi/10.1021/acs.joc.2c01292
dc.language.isoen_USen_US
dc.publisherAmerican Chemical Societyen_US
dc.subjectAmidesen_US
dc.subjectAminesen_US
dc.subjectSulfur compoundsen_US
dc.subjectamidineen_US
dc.subjectamineen_US
dc.subjectfunctional groupen_US
dc.subjectsulfonamideen_US
dc.subjectBond formationen_US
dc.subjectDirect reactionsen_US
dc.subjectDual roleen_US
dc.subjectMechanistic studiesen_US
dc.subjectMetal freeen_US
dc.subjectOne-pot proceduresen_US
dc.subjectReaction conditionsen_US
dc.subjectSecondary aminesen_US
dc.subjectSulphonamidesen_US
dc.subjectSynthetic utilityen_US
dc.subjectArticleen_US
dc.subjectcontrolled studyen_US
dc.subjectone pot synthesisen_US
dc.subjectsynthesisen_US
dc.subjectAdditivesen_US
dc.titleMetal-Free Direct Access to N-Sulfonyl Amidines from Sulfonamides and Secondary Amines Involving Tandem C-N Bond Formationsen_US
dc.title.journalJournal of Organic Chemistryen_US
dc.typeArticleen_US
dc.type.accesstypeClosed Accessen_US

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