Essential Oils: An Impending Substitute of Synthetic Antimicrobial Agents to Overcome Antimicrobial Resistance

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dc.contributor.authorPal, Rajinder
dc.contributor.authorRana, Abhilash
dc.contributor.authorJaitak, Vikas
dc.date.accessioned2019-03-26T09:06:58Z
dc.date.accessioned2024-08-13T12:06:29Z
dc.date.available2019-03-26T09:06:58Z
dc.date.available2024-08-13T12:06:29Z
dc.date.issued2019
dc.description.abstractntimicrobial resistance (AMR) is an emerging problem in the world that has a significant impact on our society. AMR made conventional drugs futile against microorganisms and diseases untreatable. Plant-derived medicines are considered safe alternatives to synthetic drugs. The active ingredients and the mixtures of these natural medicines have been used for centuries, due to their easy availability, low cost, and negligible side effects. Essential oils (EOs) are the secondary metabolites that are produced by aromatic plants to protect them from microorganisms. However, these EOs and their constituents have shown good fighting potential against drug-resistant pathogens. These oils have been proved extremely effective antimicrobial agents in comparison to antibiotics. Also, the combination of synthetic drugs with EOs or their components improves their efficacy. So, EOs can be established as an alternative to synthetic antimicrobial agents to eradicate tough form of infectious microorganisms. Due to a number of constituents, it can interact with multiple target sites, like the destruction of cytoplasm membrane or inhibition of protein synthesis and efflux pump. The purpose of this review is to provide information about the antimicrobial activity of EOs attained from different plants, their combination with synthetic antimicrobials. In addition, mechanism of antimicrobial activity of several EOs and their constituents was reported.en_US
dc.identifier.citationPal, Rajinder., Rana, Abhilash and Jaitak, Vikas (2018) Essential Oils: An Impending Substitute of Synthetic Antimicrobial Agents to Overcome Antimicrobial Resistance. Current Drug Targets. Vol. 20 (6), PP. 605 – 624. 10.2174/1389450119666181031122917en_US
dc.identifier.doi10.2174/1389450119666181031122917
dc.identifier.issn1873-5592
dc.identifier.urihttp://10.2.3.109/handle/32116/2235
dc.identifier.urlhttp://www.eurekaselect.com/166804/article
dc.language.isoenen_US
dc.publisherBentham Scienceen_US
dc.subjectAntimicrobial resistanceen_US
dc.subjectEssential oilen_US
dc.subjectMechanismen_US
dc.subjectCombination with antibioticsen_US
dc.subjectCombination of EOs and their constituentsen_US
dc.subjectSynergism.en_US
dc.titleEssential Oils: An Impending Substitute of Synthetic Antimicrobial Agents to Overcome Antimicrobial Resistanceen_US
dc.title.journalCurrent Drug Targetsen_US
dc.typeArticleen_US
dc.type.accesstypeClosed Accessen_US

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