Synthesis, biological evaluation and in-silico ADME studies of novel series of thiazolidin-2,4-dione derivatives as antimicrobial, antioxidant and anticancer agents

dc.contributor.authorKumar, Harsh
dc.contributor.authorKumar, Davinder
dc.contributor.authorKumar, Pradeep
dc.contributor.authorThareja, Suresh
dc.contributor.authorMarwaha, Minakshi Gupta
dc.contributor.authorNavik, Umashanker
dc.contributor.authorMarwaha, Rakesh Kumar
dc.date.accessioned2024-01-21T10:38:25Z
dc.date.accessioned2024-08-13T12:05:21Z
dc.date.available2024-01-21T10:38:25Z
dc.date.available2024-08-13T12:05:21Z
dc.date.issued2022-09-15T00:00:00
dc.description.abstractBackground: A novel series of thiazolidine-2,4-dione molecules was derived and their chemical structures were established using physiochemical parameters and spectral techniques (1H-NMR, IR, MS etc.). The synthesized molecule were then evaluated for their antioxidant, anticancer and antimicrobial potential. Results and discussion: Serial tube dilution method was employed to evaluate the antimicrobial potential against selected fungal and bacterial strains by taking fluconazole and cefadroxil as reference antifungal and antibacterial drugs respectively. 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity was used to assess the antioxidant potential of the synthesized analogues. Further, the anticancer potential of the selected molecules was assessed against DU-145 cancer cell lines using MTT assay. The drug-likeness was also evaluated by studying in-silico ADME parameters of the synthesized analogues. Conclusion: In antioxidant evaluation studies, the analogue H5 with IC50 = 14.85�?g/mL was found to be the most active molecule. The antimicrobial evaluation outcomes suggested that the molecules H5, H13, H15 and H18 possessed moderate to promising activity against the selected species of microbial strains having MIC range 7.3��M to 26.3��M. The results of anticancer evaluation revealed that all the screened derivatives possess mild anticancer potential. The in-silico ADME studies revealed that all the compounds were found to be drug-like. � 2022, The Author(s).en_US
dc.identifier.doi10.1186/s13065-022-00861-7
dc.identifier.issn2661801X
dc.identifier.urihttps://kr.cup.edu.in/handle/32116/3563
dc.identifier.urlhttps://bmcchem.biomedcentral.com/articles/10.1186/s13065-022-00861-7
dc.language.isoen_USen_US
dc.publisherBioMed Central Ltden_US
dc.subjectADMEen_US
dc.subjectAnticanceren_US
dc.subjectAntimicrobialen_US
dc.subjectAntioxidanten_US
dc.subjectCharacterizationen_US
dc.subjectSynthesisen_US
dc.titleSynthesis, biological evaluation and in-silico ADME studies of novel series of thiazolidin-2,4-dione derivatives as antimicrobial, antioxidant and anticancer agentsen_US
dc.title.journalBMC Chemistryen_US
dc.typeArticleen_US
dc.type.accesstypeOpen Accessen_US

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