Coumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies

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dc.contributor.authorThakur, Anuradha
dc.contributor.authorSingla, Ramit
dc.contributor.authorJaitak, Vikas
dc.date.accessioned2017-08-02T07:41:38Z
dc.date.accessioned2024-08-13T12:05:21Z
dc.date.available2017-08-02T07:41:38Z
dc.date.available2024-08-13T12:05:21Z
dc.date.issued2015
dc.description.abstractAbstract Coumarins are fused benzene and pyrone ring systems which prompt biological investigation to assess their potential therapeutic significance. It possesses immeasurable anticancer potential with minimum side effects depending on the substitutions on the basic nucleus. Coumarins have a tremendous ability to regulate diverse range of cellular pathways that can be explored for selective anticancer activity. This is the first standalone review that emphasis on the assorted retrosynthetic approaches, important targets for molecularly targeted cancer therapy and structure activity relationship studies that highlight the chemical groups responsible for evoking the anticancer potential of coumarin derivatives reported from 2011 to 2014. ? 2015 Elsevier Masson SAS.en_US
dc.identifier.citationThakur, A., Singla, R., & Jaitak, V. (2015). Coumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies. European Journal of Medicinal Chemistry, 101, 476-495. doi: 10.1016/j.ejmech.2015.07.010en_US
dc.identifier.doi10.1016/j.ejmech.2015.07.010
dc.identifier.issn2235234
dc.identifier.urihttp://10.2.3.109/handle/32116/257
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0223523415301422?via%3Dihub
dc.language.isoenen_US
dc.publisherElsevier Masson SASen_US
dc.subjectSynthesisen_US
dc.subjectAnticanceren_US
dc.subjectTargetsen_US
dc.subjectSARen_US
dc.subjectIC50en_US
dc.titleCoumarins as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studiesen_US
dc.title.journalEuropean Journal of Medicinal Chemistry
dc.typeArticleen_US

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