To Study the Dose and Time Dependent Effect of Human Insulin and Metformin on the Growth of Breast Cancer Cells
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Date
2012
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Journal Title
Journal ISSN
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Publisher
Central University of Punjab
Abstract
Cancer and diabetes, both are leading causes of mortality globally. Both the diseases
are multifactorial and share number of common risk factors. Hyperglycemia and
hyperinsulinemia which are the characteristic features of diabetes influences the growth
rate and proliferation of tumor cells directly or indirectly. Type 2 diabetes shows
stronger association with various cancers. Breast cancer is one of the malignancy
affecting females worldwide. This study demonstrates that glucose not only acts as
energy source in tumor cell but also acts as mitogen. Insulin not only regulates the
blood glucose level but also induces growth and proliferation in MCF 7 and MDA MB
231 breast cancer cell lines independently and in combination with glucose. Metformin
inhibit proliferation of MCF 7 and MDA MB 231 breast cancer cell lines independently
and also in presence of glucose and insulin, but shows more inhibitory effect in
presence of insulin as compare to glucose. Recently discovered insulin receptor
antagonist S961 did not showed any significant response in breast cancer cell lines
MCF 7 and MDA MB 231. The ineffectiveness is probably due to blocking effect of
higher insulin dose. So with this investigation it can be concluded that metabolic
alteration leads to proliferation of breast cancer cell lines.
Description
Keywords
Glucose, Insulin, Metformin, S961 Insulin Receptor
Antagonist, Hyperglycemia And Hyperinsulenemia
Citation
Cholia, Ravi Prakash (2012) To Study the Dose and Time Dependent Effect of Human Insulin and Metformin
on the Growth of Breast Cancer Cells.