A review on quinoline derived scaffolds as Anti-HIV Agents.

dc.contributor.authorChokkar, N.
dc.contributor.authorKalra, S
dc.contributor.authorChauhan, M
dc.contributor.authorKumar, Raj
dc.date.accessioned2019-03-26T09:06:58Z
dc.date.accessioned2024-08-13T12:06:31Z
dc.date.available2019-03-26T09:06:58Z
dc.date.available2024-08-13T12:06:31Z
dc.date.issued2018
dc.description.abstractAfter restricting the proliferation of CD4+T cells, Human Immunodeficiency Virus (HIV), infection persists at a very fast rate causing Acquired Immunodeficiency Syndrome (AIDS). This demands the vigorous need of suitable anti-HIV agents, as existing medicines do not provide a complete cure and exhibit drawbacks like toxicities, drug resistance, side-effects, etc. Even the introduction of Highly Active Antiretroviral Therapy (HAART) failed to combat HIV/AIDS completely. The major breakthrough in anti-HIV discovery was marked with the discovery of raltegravir in 2007, the first integrase (IN) inhibitor. Thereafter, the discovery of elvitegravir, a quinolone derivative emerged as the potent HIV-IN inhibitor. Though many more classes of different drugs that act as anti-HIV have been identified, some of which are under clinical trials, but the recent serious focus is still laid on quinoline and its analogues. In this review, we have covered all the quinoline-based derivatives that inhibit various targets and are potential anti-HIV agents in various phases of the drug discovery.en_US
dc.identifier.citationChokkar, N., Kalra.,Chauhan, M and et. al.(2018) A review on quinoline derived scaffolds as Anti-HIV Agents. Mini Reviews in Medicinal Chemistry. Vol. 19 (6), 510-526. 10.2174/1389557518666181018163448en_US
dc.identifier.doi10.2174/1389557518666181018163448
dc.identifier.issnPrint- 1389-5575
dc.identifier.issnOnline- 1875-5607
dc.identifier.urihttps://kr.cup.edu.in/handle/32116/2238
dc.identifier.urlhttp://www.eurekaselect.com/166442/article
dc.language.isoenen_US
dc.publisherBentham Scienceen_US
dc.subjectHIVen_US
dc.subjectAIDSen_US
dc.subjectAnti-retroviral agentsen_US
dc.subjectQuinolinesen_US
dc.subjectMolecular modellingen_US
dc.subjectHAART.en_US
dc.titleA review on quinoline derived scaffolds as Anti-HIV Agents.en_US
dc.title.journalMini Reviews in Medicinal Chemistryen_US
dc.typeArticleen_US
dc.type.accesstypeClosed Accessen_US

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