Phytochemicals as Potential Therapeutics for SARS-CoV-2�Induced Cardiovascular Complications: Thrombosis and Platelet Perspective

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dc.contributor.authorBeura, Samir K.
dc.contributor.authorPanigrahi, Abhishek R.
dc.contributor.authorYadav, Pooja
dc.contributor.authorSingh, Sunil K.
dc.date.accessioned2024-01-21T10:44:35Z
dc.date.accessioned2024-08-13T13:22:21Z
dc.date.available2024-01-21T10:44:35Z
dc.date.available2024-08-13T13:22:21Z
dc.date.issued2021-04-26T00:00:00
dc.description.abstractAfter gaining entry through ACE2 aided by TMPRSS2, the SARS-CoV-2 causes serious complications of the cardiovascular system leading to myocarditis and other myocardial injuries apart from causing lung, kidney and brain dysfunctions. Here in this review, we are going to divulge the cellular and immunological mechanisms behind the cardiovascular, thrombotic and platelet impairments that are caused in COVID-19. In addition, we also propose the significance of various anti-platelet and anti-thrombotic phytochemicals in the treatment of COVID-19. The virus induces many immune-modulatory cytokines and chemokines which help in the intravascular coagulation and create a pro-thrombotic environment along with pulmonary embolism and thrombocytopenia. Different types of innate and adaptive immune cells and their granular contents regulate the pathophysiology of SARS-CoV-2 induced endothelial and platelet dysfunctions which correlate the involvement of platelets with myocardial injury and intravascular thrombi directly or indirectly. Hence, by exploiting the natural bioactive compounds from medicinal plants and inhibiting the platelet mediated thrombus formation can be beneficial for the treatment of SARS-CoV-2 infection. � Copyright � 2021 Beura, Panigrahi, Yadav and Singh.en_US
dc.identifier.doi10.3389/fphar.2021.658273
dc.identifier.issn16639812
dc.identifier.urihttp://10.2.3.109/handle/32116/3801
dc.identifier.urlhttps://www.frontiersin.org/articles/10.3389/fphar.2021.658273/full
dc.language.isoen_USen_US
dc.publisherFrontiers Media S.A.en_US
dc.subjectACE2en_US
dc.subjectcytokine stormen_US
dc.subjectmyocardial injuryen_US
dc.subjectphytochemicalen_US
dc.subjectplateleten_US
dc.subjectSARS-CoV-2en_US
dc.subjectthrombosisen_US
dc.titlePhytochemicals as Potential Therapeutics for SARS-CoV-2�Induced Cardiovascular Complications: Thrombosis and Platelet Perspectiveen_US
dc.title.journalFrontiers in Pharmacologyen_US
dc.typeReviewen_US
dc.type.accesstypeOpen Accessen_US

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