Involvement of the G-Protein-Coupled Estrogen Receptor-1 (GPER) Signaling Pathway in Neurodegenerative Disorders: A Review

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dc.contributor.authorUpadhayay, Shubham
dc.contributor.authorGupta, Rishav
dc.contributor.authorSingh, Surbhi
dc.contributor.authorMundkar, Maroti
dc.contributor.authorSingh, Gursewak
dc.contributor.authorKumar, Puneet
dc.date.accessioned2024-01-21T10:55:07Z
dc.date.accessioned2024-08-14T07:44:22Z
dc.date.available2024-01-21T10:55:07Z
dc.date.available2024-08-14T07:44:22Z
dc.date.issued2022-10-28T00:00:00
dc.description.abstractThe G-protein-coupled estrogen receptor-1 (GPER) is an extranuclear estrogen receptor that regulates the expression of several downstream signaling pathways with a variety of biological actions including cell migration, proliferation, and apoptosis in different parts of the brain area. It is endogenously activated by estrogen, a steroidal hormone that binds to GPER receptors which help in maintaining cellular homeostasis and neuronal integrity as well as influences neurogenesis. In contrast, neurodegenerative disorders are a big problem for society, and still many people suffer from motor and cognitive impairments. Research to date reported that GPER has the potential to whittle down motor abnormalities and cognitive dysfunction by limiting the progression of neurodegenerative disorders. Although several findings suggest that GPER activation accelerated transcription of the PI3K/Akt/Gsk-3? and ERK1/2 signaling pathway that halt disease progression by decreasing oxidative stress, neuroinflammation, and apoptosis. Accordingly, the goal of this review is to highlight the basic mechanism of GPER signaling pathway-mediated neuroprotection in various neurodegenerative disorders including Parkinson�s disease (PD), Huntington�s disease (HD), Tardive dyskinesia (TD), and Epilepsy. This review also discusses the role of the GPER activators which might be a promising therapeutic target option to treat neurodegenerative disorders. All the data were obtained from published articles in PubMed (353), Web of Science (788), and Scopus (770) databases using the search terms: GPER, PD, HD, TD, epilepsy, and neurodegenerative disorders. � 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.en_US
dc.identifier.doi10.1007/s10571-022-01301-9
dc.identifier.issn2724340
dc.identifier.urihttp://10.2.3.109/handle/32116/4342
dc.identifier.urlhttps://link.springer.com/10.1007/s10571-022-01301-9
dc.language.isoen_USen_US
dc.publisherSpringeren_US
dc.subjectEpilepsyen_US
dc.subjectG-protein-coupled estrogen receptor-1 (GPER)en_US
dc.subjectHuntington�s disease (HD)en_US
dc.subjectNeuroprotectionen_US
dc.subjectParkinson�s diseases (PD)en_US
dc.subjectTardive dyskinesia (TD)en_US
dc.titleInvolvement of the G-Protein-Coupled Estrogen Receptor-1 (GPER) Signaling Pathway in Neurodegenerative Disorders: A Reviewen_US
dc.title.journalCellular and Molecular Neurobiologyen_US
dc.typeReviewen_US
dc.type.accesstypeClosed Accessen_US

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