Katiyar, Madhurendra K.Dhakad, Govind KumarShivaniArora, SahilBhagat, SrikantArora, TarunaKumar, Raj2024-01-212024-08-132024-01-212024-08-132022-04-0722286010.1016/j.molstruc.2022.133012https://kr.cup.edu.in/handle/32116/3539Chromene is commonly found in nature and is considered one of the most frequently used scaffolds in heterocyclic chemistry for the designing of chemical probes for therapeutic and diagnostic purposes. The chromene nucleus comprises an oxine ring fused with a phenyl ring. Owing to existing several useful biological applications of chromenes have generated wide interest among chemists to synthesize its derivatives frequently. Here, in this review, we have compiled and analysed various recently reported synthetic strategies of chromene and its derivatives through numerous approaches such as microwave-assisted, catalyst based, green solvents, solvent-free conditions, etc. along with their biological applications such as anticancer, antimicrobial, anti-inflammatory, AChE inhibition, antiviral, and antioxidant activities. � 2022 Elsevier B.V.en-USAmino acid catalysisBase catalysisChromeneNanocatalysisPharmacological activitiesSynthesisReviewhttps://linkinghub.elsevier.com/retrieve/pii/S0022286022006731