Singh, ManpreetJamra., RahulPaul, Avijit K.Malakar, Chandi C.Singh, Virender2024-01-212024-08-132024-01-212024-08-132021-12-132193580710.1002/ajoc.202100653https://kr.cup.edu.in/handle/32116/3226A simple and efficient KI promoted sulfur activation-insertion/de-nitration strategy has been developed for the synthesis of ?-carboline C1 tethered 2-acylbenzothiophenes via one-pot assembly of 1-acetyl ?-carbolines (an alkaloid based scaffold), 2-nirobenzaldehydes and elemental sulfur. This expeditious reaction proceeds through the formation of ?-carboline linked nitro-chalcones followed by embodiment of elemental sulfur to generate the multifunctional ?-carboline linked benzothiophene derivatives. The highlighted features of this efficient methodology are transition metal-free conditions, use of inexpensive and non-toxic catalyst, easy procedure, short reaction time, and broad substrate scope with good yields. The scope of this protocol has been extended for the synthesis of a range of novel compounds with significant diversity. � 2021 Wiley-VCH GmbHen-US1-Acetyl ?-carboline2-AcylbenzothiopheneDe-nitrationSulfur insertionTransition metal-freeArticlehttps://onlinelibrary.wiley.com/doi/10.1002/ajoc.202100653