Sharma, ShubhamSingh, DharmenderKumar, SunitVaishaliJamra, RahulBanyal, NaveenDeepikaMalakar, Chandi C.Singh, Virender2024-01-212024-08-132024-01-212024-08-132023-03-021860539710.3762/bjoc.19.22http://10.2.3.109/handle/32116/3269An operationally simple and metal-free approach is described for the synthesis of pyrazole-tethered thioamide and amide conjugates. The thioamides were generated by employing a three-component reaction of diverse pyrazole C-3/4/5 carbaldehydes, secondary amines, and elemental sulfur in a single synthetic operation. The advantages of this developed protocol refer to the broad substrate scope, metal-free and easy to perform reaction conditions. Moreover, the pyrazole C-3/5-linked amide conjugates were also synthesized via an oxidative amination of pyrazole carbaldehydes and 2-aminopyridines using hydrogen peroxide as an oxidant. � 2023 Sharma et al.en-USC�S/O bond formationmetal-freeoxidative amidationpyrazole carbaldehydessulfur insertionthioamidesArticlehttps://www.beilstein-journals.org/bjoc/articles/19/22