Navik, UmashankerSheth, Vaibhav G.Khurana, AmitJawalekar, Snehal SainathAllawadhi, PrinceGaddam, Ravinder ReddyBhatti, Jasvinder SinghTikoo, Kulbhushan2024-01-212024-08-142024-01-212024-08-142021-10-251568163710.1016/j.arr.2021.101500https://kr.cup.edu.in/handle/32116/4299Methionine is one of the essential amino acids and plays a vital role in various cellular processes. Reports advocate that methionine restriction and supplementation provide promising outcomes, and its regulation is critical for maintaining a healthy life. Dietary methionine restriction in houseflies and rodents has been proven to extend lifespan. Contrary to these findings, long-term dietary restriction of methionine leads to adverse events such as bone-related disorders, stunted growth, and hyperhomocysteinemia. Conversely, dietary supplementation of methionine improves hepatic steatosis, insulin resistance, inflammation, fibrosis, and bone health. However, a high level of methionine intake shows adverse effects such as hyperhomocysteinemia, reduced body weight, and increased cholesterol levels. Therefore, dietary methionine in a safe dose could have medicinal values. Hence, this review is aimed to provide a snapshot of the dietary role and regulation of methionine in the modulation of health and age-related diseases. � 2021 Elsevier B.V.en-USAgingAMPKFGF-21Insulin sensitivityMethionine restrictionMethionine supplementationmTORShort surveyhttps://linkinghub.elsevier.com/retrieve/pii/S1568163721002476