Kaur, PKumar, R.2020-07-162024-08-132020-07-162024-08-1320209312210.1007/s10593-020-02677-6https://kr.cup.edu.in/handle/32116/2663(Figure presented.) 1,2,3,4-Tetrahydroisoquinoline is an important structural motif of various natural products and therapeutic lead compounds. In recent years, considerable research interest has been witnessed toward synthesis of its C(1)-substituted derivatives, since they can act as precursors for various alkaloids displaying multifarious biological activities. This minireview offers short and non-exhaustive epitome of various multicomponent reactions for the C(1)-functionalization of 1,2,3,4-tetrahydroisoquinolines. In particular, reactions involving isomerization of iminium intermediate (exo/endo isomerization) are highlighted for the period of 2013-2019. - 2020, Springer Science+Business Media, LLC, part of Springer Nature.en-USC(1)-functionalizationheterocyclic compoundsiminium ionmulticomponent reactionstetrahydroisoquinolineArticlehttps://link.springer.com/article/10.1007%2Fs10593-020-02677-6