Patel K.Kushwaha P.Kumar S.Kumar R.2020-01-312024-08-132020-01-312024-08-1320192576642210.1021/acsabm.9b00794http://10.2.3.109/handle/32116/2492Microbial adhesion onto implanted devices was reduced by the immobilization of amino acid lysine and ?-aminoisobutyric acid to polydopamine functionalized PET films and Foley catheters. The polydopamine functionalized film was prepared by a dip coating method followed by incorporation of biocompatible amino acids to prepared films. The purpose of development of the modified pDA film is to improve the anti-biofouling and antibacterial activity of the film which can be successfully applied for medical devices. The characterization of modification was done using different techniques such as contact angle measurement, ATR-FTIR, FE-SEM, AFM, and XPS analysis. ATR-FTIR spectroscopy and XPS confirmed the successful amino modification of film. The anti-biofouling and antimicrobial behavior of the prepared surfaces were evaluated using the bacterial attachment and death assay. The resulting coatings repelled bacterial cell attachment and killed clinically applicable Gram-negative and Gram-positive strains. The developed coatings were applied to the Foley catheters to study the antibacterial activity by the log reduction method. The results demonstrate that tested amino acid-modified film increases the antibacterial activity of the catheters and can significantly help in reduction of nosocomial infections.enamino acidsanti-biofoulingantibacterial coatingbacterial attachment and death assayFoley catheterslog reduction methodpolydopamineArticlehttps://pubs.acs.org/doi/abs/10.1021/acsabm.9b00794