Barwal, Tushar SinghSingh, NehaSharma, UttamBazala, SonaliRani, MedhaBehera, AlishaKumawat, Ram KumarKumar, PawanUttam, VivekKhandelwal, AkankshaBarwal, JyotiJain, ManjuJain, Aklank2024-01-162024-08-132024-01-162024-08-132022-06-122468294210.1016/j.ctarc.2022.100593https://doi.org/10.1016/j.ctarc.2022.100593http://10.2.3.109/handle/32116/2882Accumulating evidence suggests the critical role of miR-590�5p in various aspects of cellular homeostasis, including cancer. Furthermore, we and others have recently demonstrated that miRNA-590�5p acts as an oncogene in some cancers while it acts as a tumor-suppressor in others. However, the role of miR-590�5p in oncogenesis is more complex, like a double-edged sword. Thus, this systematic review introduces the concept, mechanism, and biological function of miR-590�5p to resolve this apparent paradox. We have also described the involvement of miR-590�5p in crucial cancer-hallmarks processes like proliferation, invasion, metastasis, and chemo radioresistance. Finally, we have presented the possible genes/pathways targets of miR-590�5p through bioinformatics analysis. This review may help in designing better biomarkers and therapeutic targets for cancers. � 2022en-USBiomarkerCancerMicroRNAmiR-590-5pTherapeutic targetReview