Kulkarni, SwanandGupta, KhushiRatre, PoojaMishra, Pradyumna KumarSingh, YogeshBiharee, AvadhThareja, Suresh2024-01-212024-08-132024-01-212024-08-132023-11-051359644610.1016/j.drudis.2023.103821http://10.2.3.109/handle/32116/3625Polycystic ovary syndrome (PCOS) prevails in approximately 33% of females of reproductive age globally. Although the root cause of the disease is unknown, attempts are made to clinically manage the disturbed hormone levels and symptoms arising due to hyperandrogenism, a hallmark of PCOS. This review presents detailed insights on the etiology, risk factors, current treatment strategies, and challenges therein. Medicinal agents currently in clinical trials and those in the development pipeline are emphasized. The significance of the inclusion of herbal supplements in PCOS and the benefits of improved lifestyle are also explained. Last, emerging therapeutic targets for treating PCOS are elaborated. The present review will assist the research fraternity working in the concerned domain to access significant knowledge associated with PCOS. � 2023 Elsevier Ltden-USReviewhttps://linkinghub.elsevier.com/retrieve/pii/S1359644623003379