Singh, ManpreetVaishaliJamra, RahulDeepikaKumar, SunitSingh, Virender2024-01-212024-08-132024-01-212024-08-132022-09-152365654910.1002/slct.202202392https://kr.cup.edu.in/handle/32116/3253A simple and efficient iodine catalysed protocol has been unfolded for the synthesis of novel ?-carboline C1-linked ?-amino amidines via one-pot assembly of 1-formyl ?-carbolines (Kumujian C analogues), anilines and isocyanides. This domino strategy proceeds through the formation of three C?N bonds in a single operation. The advantageous features of the developed methodology include one-pot synthesis, operational simplicity, high atom economy, broad substrate scope, multicomponent character, easy purification procedure (no column chromatography) and applicability towards gram scale synthesis. The scope of strategy has been demonstrated with the construction of a library of 32 novel ?-carboline tethered ?-amino amidines having three points of diversity. � 2022 Wiley-VCH GmbH.en-USIodine catalysedKumujian CUgi-type reaction?-Amino amidines?-carbolineArticlehttps://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202202392