Pandey, Vishakha2018-08-312024-08-132018-08-312024-08-132018Pandey, Vishakha (2018) Synthesis And Antiproliferative Activity Of Pyrazole-Based Heterocycleshttp://10.2.3.109/handle/32116/1936Among the various heterocyclic compounds pyrazole and its derivatives have occupied wide range of biological and pharmacological activities. These were observed for their modes of function in the inhibition of topoisomerase and DNA repair. DNA topoisomerases usually modify DNA topology by their ability to break and reseals both its strands. Which were leads to DNA replication, transcription processes. It helps as a vital targets for numerous chemotherapeutic agents. The potency of topoisomerase inhibitors looks to be diminishing due to drug resistance and lack of efficacy. Thus, after long glimpsing the current scenario was made in order to develop topoisomerase inhibitors with completely new scaffold or alteration or modification in the existing scaffold. We herein report design and synthesis of pyrazole based compounds as topoisomerase inhibitors. The synthetics were evaluated for their in vitro anticancer activity against MDAMB 231 breast cancer cell line.en-USCancerResistanceTopoisomerasePyrazoleSynthesisMaster DissertationT00746