Mukherjee, Anirban GoutamWanjari, Uddesh RameshGopalakrishnan, Abilash ValsalaKannampuzha, SandraMurali, ReshmaNamachivayam, ArunrajGanesan, RajaRenu, KaviyarasiDey, AbhijitVellingiri, BalachandarPrabakaran, D.S.2024-01-212024-08-132024-01-212024-08-132023-02-232076393X10.3390/vaccines11030510https://kr.cup.edu.in/handle/32116/3848COVID-19 has become a significant public health concern that has catastrophic consequences for society. Some preliminary evidence suggests that the male reproductive system may be an infection target for SARS-CoV-2. SARS-CoV-2 may be transmitted sexually, according to preliminary research. Testicular cells exhibit a high level of the angiotensin-converting enzyme 2 (ACE2) receptor, which enhances the entry of the SARS-CoV-2 into host cells. Some instances of COVID-19 have been documented to exhibit hypogonadism during the acute stage. Furthermore, systemic inflammatory reactions triggered by SARS-CoV-2 infection may cause oxidative stress (OS), which has been shown to have profoundly deleterious consequences on testicular functioning. This work gives a clear picture of how COVID-19 may affect male reproductive systems and calls attention to the many unanswered questions about the mechanisms by which this virus can be linked to men�s health and fertility. � 2023 by the authors.en-USimmunologymale infertilityreproductive toxicitySARS-CoV-2Reviewhttps://www.mdpi.com/2076-393X/11/3/510