Kumar, BhupenderBorah, BiplobBabu, J. NagendraChowhan, L. Raju2024-01-212024-08-132024-01-212024-08-132022-10-272046206910.1039/d2ra05994khttp://10.2.3.109/handle/32116/3258A composite of copper ferrite oxide nanoparticles immobilized on microcrystalline cellulose (CuFe2O4@MCC) was synthesized. The synthesized composite was characterized by FESEM with EDS-Mapping, TEM, P-XRD, TEM, and BET analysis and investigated for its catalytic activity toward Tandem Michael addition and decarboxylation of coumarin-3-carboxylic acid with cyclic 1,3-diketones to obtain novel 3,4-dihydrocoumarin derivatives. This protocol was established with wide substrate scope and significant yield. The significant characteristics of this methodology are mild reaction conditions, easy setup procedure, non-toxic, and cost-effectiveness. A gram-scale synthesis with low catalyst loading was also demonstrated. � 2022 The Royal Society of Chemistry.en-USCopperCost EffectivenessDecarboxylationLoadingMicrOCRystalline CelluloseTransmission Electron MicroscopyCarboxylationCatalyst activityCelluloseCopper alloysCopper oxidesFerriteNanoparticlesSynthesis (chemical)Copper ferritesDecarboxylation reactionsDihydrocoumarinsEco-friendlyFerrite nanoparticlesMichael additionsMicro-crystalline celluloseOxide nanoparticlesReaction catalyzedSynthesisedCost effectivenessArticlehttp://xlink.rsc.org/?DOI=D2RA05994K