Chhabra, Ravindresh2024-01-162024-08-132024-01-162024-08-132022-09-169780323919098978032391950010.1016/B978-0-323-91909-8.00010-4https://doi.org/10.1016/B978-0-323-91909-8.00010-4https://kr.cup.edu.in/handle/32116/2890DNA, RNA, and the proteins are the major players in the flow of genetic information. Out of these, RNA is the most versatile biomolecule as it exists in multiple forms and each form carries out specified functions in the cell. RNA can be classified into coding and noncoding RNA (ncRNA). The noncoding RNA is further subdivided into long noncoding RNA (>200 nucleotides) and small noncoding RNA (<200 nucleotides). The coding RNA is the one which gets translated into proteins; whereas, the ncRNA is usually responsible for the regulation of gene expression. The ncRNA has been implicated in a number of pathological conditions including cancer, diabetes, neurological disorders and developmental defects. The interplay between ncRNAs and epigenetics often plays a significant role in the onset and progression of some of the aforementioned diseases. This chapter elaborates on the different ways in which epigenetic phenomenon is regulated by ncRNA and the effect of epigenetic modification on the expression of ncRNA. � 2023 Elsevier Inc. All rights reserved.en-UScircRNADNMTlncRNAm5Cm6AmiRNApiRNARNA methylationBook chapter