Selvam, ChelliahThilagavathi, RamasamyNarasimhan, BalasubramanianKumar, PradeepJordan, Brian C.Ranganna, KasturiSelvam, C.Thilagavathi, R.Narasimhan, B.Kumar, P.Jordan, B.C.Ranganna, K.2017-08-012024-08-132017-08-012024-08-132016Selvam, C., Thilagavathi, R., Narasimhan, B., Kumar, P., Jordan, B. C., & Ranganna, K. (2016). Computer-aided design of negative allosteric modulators of metabotropic glutamate receptor 5 (mGluR5): Comparative molecular field analysis of aryl ether derivatives. Bioorganic and Medicinal Chemistry Letters, 26(4), 1140-1144. doi: 10.1016/j.bmcl.2016.01.0510960894X10.1016/j.bmcl.2016.01.051https://kr.cup.edu.in/handle/32116/241The metabotropic glutamate receptors (mGlu receptors) have emerged as attractive targets for number of neurological and psychiatric disorders. Recently, mGluR5 negative allosteric modulators (NAMs) have gained considerable attention in pharmacological research. Comparative molecular field analysis (CoMFA) was performed on 73 analogs of aryl ether which were reported as mGluR5 NAMs. The study produced a statistically significant model with high correlation coefficient and good predictive abilities. ? 2016enAlkyl Aryl EtherMetabotropic Receptor 5Ether DerivativeMetabotropic Receptor 5Protein BindingAllosterism Binding SiteChemical StructureComparative Molecular Field AnalysisComputer Aided DesignMental DiseaseProcess OptimizationQuantitative AnalysisStatic ElectricityStructure Activity RelationAllosterismChemistryComputer Aided DesignConformationIc50MetabolismQuantitative Structure Activity RelationAllosteric RegulationComputer-Aided DesignEthArticlehttps://www.sciencedirect.com/science/article/pii/S0960894X16300518?via%3Dihub