Sharma, AditiSingh, ArvindPriya, AnuKaur, ManmeetGupta, Vivek KumarJaitak, VikasBanerjee, Bubun2024-01-212024-08-132024-01-212024-08-132022-07-2239791110.1080/00397911.2022.2101378https://kr.cup.edu.in/handle/32116/3553A facile and convenient method has been developed for the one-pot pseudo-four component synthesis of fully functionalized pyridine derivatives from the reactions of aromatic aldehydes, malononitrile and thiols in the presence of a catalytic amount of trisodium citrate dihydrate as an efficient metal-free catalyst in aqueous ethanol under refluxed conditions. All the reactions were completed within just 45 minutes and the desired products afforded in excellent yields (90�95%). Gram scale production of the desired compound was also achieved. Synthesis of biologically promising scaffolds, high atom economy, excellent yields, use of metal-free catalyst, less toxic solvents, no column chromatographic purifications, reusability of the solvent media, multiple carbon-carbon and carbon-heteroatom bond formations are some of the major advantages of this newly developed protocol. � 2022 Taylor & Francis Group, LLC.en-USFully functionalized pyridinesmetal-free synthesismulticomponent reactionssustainable developmentstrisodium citrate dihydrateArticlehttps://www.tandfonline.com/doi/full/10.1080/00397911.2022.2101378