Amanat, MuhammedGautam, SwatiChalotra, RishabhLal, KanhaiyaGupta, TanyaAgrawal, RohiniMojwar, SomduttSingh, Randhir2024-01-212024-08-142024-01-212024-08-142023-05-072667142510.1016/j.prmcm.2023.100258http://10.2.3.109/handle/32116/4372Introduction: A perennial, aromatic, tuberose plant Zingiber roseum (Roscoe.) (Zingiberaceae), flourishes in tropical and subtropical climates. In Traditional Chinese Medicine, several pharmacological properties of Zingiber roseum have been reported its antiseptic, antivertigo, and antidiarrheal activities. Therefore, the present article aims to provide insights into the ethnomedicinal, phytochemistry, and pharmacology of Zingiber roseum. Methods: The literature was compelled after systematically searching scientific databases, including Scopus, PubMed, Google Scholar, and Research Gate. The selection criteria for the plant comprised the therapeutic potential of Zingiber roseum and its active components. Moreover, to explore anti-diabetic activity, ligands of interest from Z. roseum were evaluated for their affinity towards PPAR-? and PPAR-?. Results and discussions: Out of 200 articles, 140 were selected for the current study, and from the para-topic literature, it was found that Zingiber roseum has numerous pharmacological properties due to the presence of phytoconstituents like flavonoids, alkaloids, phenolic chemicals, terpenoids, saponins, and phytosterols. Furthermore, in silico studies were carried out using PyRx. It was found that rosmarinic acid (-8.3 kcal/mol) and stigmasterol (-11.12 kcal/mol) exhibited the highest binding affinities for PPAR-? and PPAR-?, respectively, when compared to standard Rosiglitazone. Conclusion: It may be concluded that Z. roseum has several therapeutic activities. Moreover, in silico studies revealed the anti-diabetic action of Z. roseum via modulation of PPAR-? and PPAR-?. � 2023 The Author(s)en-USPAR-?PAR-?Rosmarinic acidSitgmasterolZingiber roseumZingiberaceaeReviewhttps://linkinghub.elsevier.com/retrieve/pii/S2667142523000441