Kopchuk D.S.Chepchugov N.V.Kovalev I.S.Santra S.Rahman M.Giri K.Zyryanov G.V.Majee A.Charushin V.N.Chupakhin O.N.2019-03-222024-08-132019-03-222024-08-132017Kopchuk D.S., Chepchugov N.V., Kovalev I.S. et.al. (2017) Solvent-free synthesis of 5-(aryl/alkyl)amino-1,2,4-triazines and ?-arylamino-2,2?-bipyridines with greener prospects2046206910.1039/c6ra26305dhttps://kr.cup.edu.in/handle/32116/2057A green and highly efficient method has been developed for the synthesis of 5-(aryl/alkyl)amino-1,2,4-triazines and ?-arylamino-2,2?-bipyridines according to the principles of atom economy. It has been performed by two consecutive solvent-free reaction pathways: the ipso-substitution of a cyano-group in 5-cyano-1,2,4-triazines and the aza-Diels-Alder reaction of the resulting 5-arylamino-1,2,4-triazines with 1-morpholinocyclopentene used as a dienophile. Solvent and catalyst-free conditions, operational simplicity, the compatibility with various functional groups, nonchromatographic purification technique, and high yields are the notable advantages of this procedure. The present methodology possesses a low E-factor.Article