Sharma, PrernaRani, NidhiGangwar, AishwaryaSingh, RandhirKaur, RajwinderUpadhyaya, Kumud2024-01-212024-08-142024-01-212024-08-142022-08-181573399810.2174/1573399819666220817121551http://10.2.3.109/handle/32116/4332Diabetes mellitus is a crucial health issue worldwide. The worldwide ubiquity is 8.8% among adults, which is predicted to rise to 10.4% by 2040. Diabetic neuropathy is a long-term complication associated with the diabetes mellitus condition, which primarily targets Schwann cells, peripheral axons and cell bodies (perikarya) in DRG (dorsal root ganglia). It can be accom-panied by different factors such as metabolic factors such as insulin resistance, hypertension, obe-sity, low HDL level, and hypertriglyceridemia. The etiology of DPN is multifactorial. It is caused by hyperglycemia, micro-angiopathy, HbA1c, duration of diabetes, smoking status, high-density lipoprotein cholesterol and hypertension. Also, increased glucose conditions decrease vitamin D levels. Vitamin D, which is involved in neurotrophins such as NGF (nerve growth factor) and NCH (neuronal calcium homeostasis), plays a neuroprotective role in peripheral nerves. Depletionleads to vitamin D deficiency which further develops peripheral neuropathy in diabetic patients. Accu-mulation of AGEs (advanced glycation end product) plays a significant role in the pathogenesis of sensory neuronal damage. It contributes to microangiopathy and endoneurial vascular dysfunction in peripheral nerves. With vitamin D supplementation, the neuropathy pain scores were improved. � 2023 Bentham Science Publishers.en-UScholecalciferolDiabetesdiabetic neuropathyHbA1chyperglycemiavitamin D deficiencyReviewhttps://www.eurekaselect.com/207592/article