Relay tricyclic Pd (ii)/Ag (i) catalysis: design of a four-component reaction driven by nitrene-transfer on isocyanide yields inhibitors of EGFR.

Sawant, D.M.Sharma, SPathare, R.SJoshi, GKalra, SSukanya, SMaurya, A.K.Metre, R.KAgnihotri, V.K.Khan, S.Kumar, RajPardasania, R. T.2019-03-262024-08-132019-03-262024-08-132018Sawant, D.M., Sharma, S., Pathare, R.S and et. al. (2018) Relay tricyclic Pd (ii)/Ag (i) catalysis: design of a four-component reaction driven by nitrene-transfer on isocyanide yields inhibitors of EGFR. Chemical Communications. Vol. 54 (82), PP. 11530-11533. 10.1039/C8CC05845HPrint- 1359-7345Online- 1364-548X10.1039/C8CC05845Hhttps://kr.cup.edu.in/handle/32116/2246Synthesis of pyrazolo[1,5-c]quinazolines from four easily available precursors is presented through a one-pot tricyclic Pd(II)/Ag(I) relay catalysis. The bimetallic relay cascade forges five new chemical bonds by concatenating six discrete chemical steps. The relay catalysis enables four-component assembly of pyrazolo[1,5-c]quinazolines that selectively inhibit EGFR, exhibit apoptosis through the ROS-induced mitochondrial-mediated pathway, and arrest the cell cycle at the G1 phase.enRelay tricyclic Pd (ii)/Ag (i) catalysis: design of a four-component reaction driven by nitrene-transfer on isocyanide yields inhibitors of EGFR.Articlehttps://pubs.rsc.org/en/content/articlelanding/2018/cc/c8cc05845h#!divAbstractChemical Communications