Jongbloets, Bart C.Lemstra, SuzanneSchellino, RobertaBroekhoven, Mark H.Parkash, JyotiHellemons, Anita J.C.G.M.Mao, TianyiGiocobini, PaoloPraag, Henriette VanMarchis, Silvia DeRamakers, Geert M.J.Pasterkamp, R. JeroenJongbloets, B.C.Lemstra, S.Schellino, R.Broekhoven, M.H.Parkash, J.Hellemons, A.J.C.G.M.Mao, T.Giacobini, P.Van Praag, H.De Marchis, S.Ramakers, G.M.J.Pasterkamp, R.J.2018-01-052024-08-132018-01-052024-08-132017Jongbloets, B. C., Lemstra, S., Schellino, R., Broekhoven, M. H., Parkash, J., Hellemons, A. J. C. G. M., . . . Pasterkamp, R. J. (2017). Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors. Nature Communications, 8. doi: 10.1038/ncomms146662041172310.1038/ncomms14666https://kr.cup.edu.in/handle/32116/500The guidance protein Semaphorin7A (Sema7A) is required for the proper development of the immune and nervous systems. Despite strong expression in the mature brain, the role of Sema7A in the adult remains poorly defined. Here we show that Sema7A utilizes different cell surface receptors to control the proliferation and differentiation of neural progenitors in the adult hippocampal dentate gyrus (DG), one of the select regions of the mature brain where neurogenesis occurs. PlexinC1 is selectively expressed in early neural progenitors in the adult mouse DG and mediates the inhibitory effects of Sema7A on progenitor proliferation. Subsequently, during differentiation of adult-born DG granule cells, Sema7A promotes dendrite growth, complexity and spine development through ?1-subunit-containing integrin receptors. Our data identify Sema7A as a key regulator of adult hippocampal neurogenesis, providing an example of how differential receptor usage spatiotemporally controls and diversifies the effects of guidance cues in the adult brain.enAlpha1 IntegrinAlpha5 IntegrinBeta1 IntegrinCaspase 3Cell Surface ReceptorCre RecombinaseDoublecortinGlial Fibrillary Acidic ProteinKi 67 AntigenNestinPlexinPlexin C1SemaphorinSemaphorin 7AT Box Brain Protein 2T Box Transcription FactorTranscription Factor Sox2Unclassified DrugBrainComplexityDifferentiationGrowthImmune SystemProteinRodentAdultAnimal CellAnimal ExperimentAnimal TissueApoptosis Cell DensityCell DifferentiationArticlehttps://www.nature.com/articles/ncomms14666