Rani, NidhiSingh, RandhirKumar, PraveenSharma, PrernaSharma, Vikas2024-01-212024-08-142024-01-212024-08-142022-04-052211352510.2174/2211352520666220404093338http://10.2.3.109/handle/32116/4315Background: Since December 2019, COVID-19 has become a new health crisis in the world and has been declared a public health emergency of international concern by WHO. In search of anti-COVID treatment regimen, we applied molecular docking approach in order to identify the natural compounds that may have potential for anti-COVID treatment with specific target and selective inhibitory mechanism. Our goal is to identify the potential anti-COVID compounds based on virtual screening of the protein of spike glycoprotein as virtual inhibition target. Methods: Molecular docking was carried out by using Molergo Virtual Docker. 35 compounds from different plant sources were selected and docked in the enzyme pocket. Results: The docking result revealed that some of the compounds exhibited good potency against the virus and can be used further for developing new drug regimen. Conclusion: The compounds of natural origin could be a good target and can be used as lead compounds for the treatment of this dreadful disease. � 2023 Bentham Science Publishers.en-USCoronavirusCOVID19MERSnatural plantsspike glycoproteinWHOArticlehttps://www.eurekaselect.com/203043/article