Saifi, Mohd AslamPoduri, RamaraoGodugu, Chandraiah2024-01-212024-08-132024-01-212024-08-132021-02-189789811555343978981155533610.1007/978-981-15-5534-3_13https://kr.cup.edu.in/handle/32116/3512The expanding horizon of nanotechnology has covered most of the parts of our life including general household items to drug delivery and therapeutics. The progresses made in the nanotechnology field provided us some of the clinically useful nano-based products apart from the more than 50 products in pipeline. However, as these products are intended for human use, they also raise some critical safety concerns primarily due to their altered physicochemical properties different from the bulk. Further, the use of nanocarriers has also been found to be associated with different unwanted toxicological observations which depends on different factors. Hence, the safe and efficacious use of these nanocarriers strictly entails the comprehensive and thorough knowledge of the toxicological potential of nanocarriers. Further, the harmonious integration of academia, researcher, industries and regulatory bodies is warranted to ensure the proper regulation of their use. � Springer Nature Singapore Pte Ltd. 2021.en-USInflammationMembrane damageNanomedicineNanotoxicologyOxidative stressRegulatory guidelinesBook chapterhttp://link.springer.com/10.1007/978-981-15-5534-3_13