Kopchuk, Dmitry S.Chepchugov, Nikolay V.Kovalev, Igor S.Santra, SougataRahman, MatiurGiri,KousikZyryanov, Grigory V.Majee, AdinathCharushin, Valery N.Chupakhin, Oleg N.2018-01-312024-08-132018-01-312024-08-132017Kopchuk, Dmitry S., Chepchugov, Nikolay V., Kovalev, Igor S. and et. al. Solvent-free synthesis of 5-(aryl/alkyl)amino-1,2,4- triazines and a-arylamino-2,2 0 -bipyridines with greener prospects (2017) RSC Adv., 2017, 7, 9610Online- 2046-206910.1039/c6ra26305dhttps://kr.cup.edu.in/handle/32116/551A green and highly efficient method has been developed for the synthesis of 5-(aryl/alkyl)amino-1,2,4-triazines and α-arylamino-2,2′-bipyridines according to the principles of atom economy. It has been performed by two consecutive solvent-free reaction pathways: the ipso-substitution of a cyano-group in 5-cyano-1,2,4-triazines and the aza-Diels-Alder reaction of the resulting 5-arylamino-1,2,4-triazines with 1-morpholinocyclopentene used as a dienophile. Solvent and catalyst-free conditions, operational simplicity, the compatibility with various functional groups, nonchromatographic purification technique, and high yields are the notable advantages of this procedure. The present methodology possesses a low E-factor.enArticlehttp://pubs.rsc.org/en/Content/ArticleLanding/2017/RA/C6RA26305D#!divAbstract