Vaishali, NoneMalakar, Chandi C.Singh, Virender2024-01-212024-08-132024-01-212024-08-132022-12-011144054610.1039/d2nj04620bhttp://10.2.3.109/handle/32116/3260A potential three component reaction strategy has been devised to generate nature inspired ?-carboline N-fused pyrroles containing pyridine tethers. These scaffolds were afforded in high yields via a one-pot cascade regioselective reaction of diverse Kumujian C, 2-aminopyridines and alkyne derivatives under Cu(ii)-catalysis. A library of 32 novel indolizino[8,7-b]indole derivatives with pyridine tethers has been developed. The current protocol offers excellent regioselectivity, high atom-economy and significant structural diversity. � 2023 The Royal Society of Chemistry.en-USBiomimetic processesCopper compoundsRegioselectivityScaffoldsSynthesis (chemical)Tetherlinesalkyne derivativebeta carboline derivativecopperindole derivativeindolizino[8,7 b]indole derivativepyridinepyrrole derivativeunclassified drug2-AminopyridineFused pyrroleHigher yieldOne potPyrrole derivativesReaction strategiesRegioselective reactionsRegioselective synthesisThree component reactions?-carbolineArticlecatalysischemical structurecross coupling reactioneconomic aspectone pot synthesisregioselectivitysynthesisPyridineArticlehttp://xlink.rsc.org/?DOI=D2NJ04620B